Publications

>	Keum, S., Hwang, Y., Lee, M., Song, S., Jeong, J., Hwang, Y. E., Choi, J. H., Kim, J. W., & Rhee, S. (2025). Targeting dual-specificity phosphatase 23 to overcome chemoresistance and stem cell-like behavior in non-small cell lung cancer cells. Scientific reports, 15(1), 40770. https://doi.org/10.1038/s41598-025-24452-3 [Pubmed ]
>	Song, S., Ko, P., Keum, S., Jeong, J., Hwang, Y. E., Lee, M., Choi, J. H., Jung, Y. S., Kim, S. H., & Rhee, S. (2024). Microtubule acetylation and PERK activation facilitate eribulin-induced mitochondrial calcium accumulation and cell death. Cellular and molecular life sciences : CMLS, 82(1), 32. https://doi.org/10.1007/s00018-024-05565-w [Pubmed ]
>	Song, S., & Rhee, S. (2024).CKAP4 is a potential therapeutic target to overcome resistance to EGFR-TKIs in lung adenocarcinoma. Genes & genomics, 47(3), 331–340. https://doi.org/10.1007/s13258-024-01606-7 [Pubmed ]
>	Keum, S., Lee, Y. J., Kim, J. W., & Rhee, S. (2024). Dual-specificity phosphatase 23 functions as a promising prognostic biomarker in non-small cell lung cancer. Genes & genomics, 47(3), 321–329. https://doi.org/10.1007/s13258-024-01604-9 [Pubmed ]
>	An, M. J., Kim, J. Y., Kim, J., Kim, D. H., Shin, G. S., Lee, H. M., Jo, A. R., Park, Y., Hwangbo, Y., Kim, C. H., Kim, M. J., Jung, Y. S., Kim, J., Rhee, S., Seo, S. B., & Kim, J. W. (2024). Reorganization of H3K9me heterochromatin leads to neuronal impairment via the cascading destruction of the KDM3B-centered epigenomic network. iScience, 27(8), 110380. https://doi.org/10.1016/j.isci.2024.110380 [Pubmed ]
>	Choi, J. H., Jeong, J., Kim, J., You, E., Keum, S., Song, S., Hwang, Y. E., Ji, M., Park, K. S., & Rhee, S. (2024). Genetic disruption of ATAT1 causes RhoA downregulation through abnormal truncation of C/EBPβ. BMB report, 57(6), 293–298. [Pubmed ]
>	Lee, H. W., Choi, J. H., Seo, D., Gavaachimed, L., Choi, J., Park, S., Min, N. Y., Lee, D. H., Bang, H. W., Ham, S. W., Kim, J. W., Lee, S. C., Rhee, S, Seo, S. B., & Lee, K. H. (2024). EGCG-induced selective death of cancer cells through autophagy-dependent regulation of the p62-mediated antioxidant survival pathway. Biochimica et biophysica acta. Molecular cell research, 1871(3), 119659. https://doi.org/10.1016/j.bbamcr.2024.119659 [Pubmed ]
>	Jeong, J., Kim, O. H., Shim, J., Keum, S., Hwang, Y. E., Song, S., Kim, J. W., Choi, J. H., Lee, H. J., & Rhee, S. (2023). Microtubule acetylation induced by oxidative stress regulates subcellular distribution of lysosomal vesicles for amyloid-beta secretion. Journal of cellular physiology, 10.1002/jcp.31131. Advance online publication. [Pubmed ]
>	Jeong, J., Hwang, Y. E., Lee, M., Keum, S., Song, S., Kim, J. W., Choi, J. H., & Rhee, S. (2023). Downregulation of AP1S1 causes the lysosomal degradation of EGFR in non-small cell lung cancer. Journal of cellular physiology, 238(10), 2335–2347. [Pubmed ]
>	Ahn, S., Kwon, A., Oh, Y., & Rhee, S., & Song, W. K. (2023). Microtubule Acetylation-Specific Inhibitors Induce Cell Death and Mitotic Arrest via JNK/AP-1 Activation in Triple-Negative Breast Cancer Cells. Molecules and cells, 46(6), 387–398. https://doi.org/10.14348/molcells.2023.2192 [Pubmed ]
>	Ahn, S., Kwon, A., Huh, Y. H., Rhee, S., & Song, W. K. (2022). Tumor-derived miR-130b-3p induces cancer-associated fibroblast activation by targeting SPIN90 in luminal A breast cancer. Oncogenesis, 11(1), 47. [Pubmed ]
>	You, E., Jeong, J., Lee, J., Keum, S., Hwang, Y. E., Choi, J. H., & Rhee, S. (2022). Casein kinase 2 promotes the TGF-β-induced activation of α-tubulin acetyltransferase 1 in fibroblasts cultured on a soft matrix. BMB reports, 55(4), 192–197.[Pubmed ]
>	Keum, S., Yang, S. J., Park, E., Kang, T., Choi, J. H., Jeong, J., Hwang, Y. E., Kim, J. W., Park, D., & Rhee, S. (2021). Beta-Pix-dynamin 2 complex promotes colorectal cancer progression by facilitating membrane dynamics. Cellular oncology, Advance online publication. [Pubmed ]
>	Ko, P., Choi, J. H., Song, S., Keum, S., Jeong, J., Hwang, Y. E., Kim, J. W., & Rhee, S. (2021). Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress. International journal of molecular sciences, 22(11), 6018. [Pubmed ]
>	Kang, D. H., Lee, T. J., Kim, J. W., Shin, Y. S., Kim, J. D., Ryu, S. W., Ryu, S., Choi, Y. H., Kim, C. H., You, E., Rhee, S., Song, K. S., et al. (2020). Down-regulation of diesel particulate matter-induced airway inflammation by the PDZ motif peptide of ZO-1. Journal of cellular and molecular medicine 10.1111/jcmm.15843. Advance online publication. [Pubmed ]

>	Kwon, A., Lee, G. B., Park, T., Lee, J. H., Ko, P., You, E., Ahn, J. H., Eom, S. H., Rhee, S., Song, W. K., et al. (2020). Potent Small-Molecule Inhibitors Targeting Acetylated Microtubules as Anticancer Agents Against Triple-Negative Breast Cancer. Biomedicines 8(9), E338. [Pubmed ]
>	You, E., Ko, P., Jeong, J., Keum, S., Kim, J.W., Seo, Y.J., Song, W.K., Rhee, S., et al. (2020). Dynein-mediated nuclear translocation of yes-associated protein through microtubule acetylation controls fibroblast activation. Cell Mol Life Sci 77(20), 4143-4161. [Pubmed ]
>	Kwon, A., Chae, I. H., You, E., Kim, S. H., Ahn, S. Y., Lee, O. J., Park, Z. Y., Rhee, S., Huh, Y. H., Song, W. K., et al. (2020). Extra domain A-containing fibronectin expression in Spin90-deficient fibroblasts mediates cancer-stroma interaction and promotes breast cancer progression. Journal of cellular physiology 235(5), 4494–4507. [Pubmed ]
>	Lee, J., Ko, P., You, E., Jeong, J., Keum, S., Kim, J., Rahman, M., Lee, D. H., Rhee, S., et al. (2019). Shwachman-Bodian-Diamond syndrome protein desensitizes breast cancer cells to apoptosis in stiff matrices by repressing the caspase 8-mediated pathway. Animal cells and systems 23(6), 414–421. [Pubmed ]
>	You, E., Huh, Y.H., Lee, J., Ko, P., Jeong, J., Keum, S., Kim, J., Kwon, A., Song, W.K., Rhee, S., et al. (2019). Downregulation of SPIN90 promotes fibroblast activation via periostin-FAK-ROCK signaling module. Journal of cellular physiology 234(6), 9216-9224. [Pubmed ]
>	Kang, J.Y., Kim, J.Y., Kim, K.B., Park, J.W., Cho, H., Hahm, J.Y., Chae, Y.C., Kim, D., Kook, H., Rhee, S., et al. (2018). KDM2B is a histone H3K79 demethylase and induces transcriptional repression via sirtuin-1-mediated chromatin silencing. FASEB J 32, 5737-5750. [Pubmed ]
>	Jeong, J., Keum, S., Kim, D., You, E., Ko, P., Lee, J., Kim, J., Kim, J.W., and Rhee, S. (2018). Spindle pole body component 25 homolog expressed by ECM stiffening is required for lung cancer cell proliferation. Biochem Biophys Res Commun 500, 937-943. [Pubmed ]
>	Ha, S., Jeong, J., Oh, J., Rhee, S., and Ham, S.W. (2018). A Small Organic Molecule Blocks EGFR Transport into the Nucleus by the Nonclassical Pathway Resulting in Repression of Cancer Invasion. Chembiochem 19, 131-135. [Pubmed ]
>	An, M.J., Kim, C.H., Nam, G.Y., Kim, D.H., Rhee, S., Cho, S.J., and Kim, J.W. (2018). Transcriptome analysis for UVB-induced phototoxicity in mouse retina. Environ Toxicol 33, 52-62. [Pubmed ]
>	You, E., Huh, Y.H., Kwon, A., Kim, S.H., Chae, I.H., Lee, O.J., Ryu, J.H., Park, M.H., Kim, G.E., Lee, J.S., Lee K.H., Lee Y.S., Kim J.W., Rhee. S., and Song W.K. (2017). SPIN90 Depletion and Microtubule Acetylation Mediate Stromal Fibroblast Activation in Breast Cancer Progression. Cancer Res 77, 4710-4722. [Pubmed ]
>	Oh, S., You, E., Ko, P., Jeong, J., Keum, S., and Rhee, S. (2017). Genetic disruption of tubulin acetyltransferase, alphaTAT1, inhibits proliferation and invasion of colon cancer cells through decreases in Wnt1/beta-catenin signaling. Biochem Biophys Res Commun 482, 8-14. [Pubmed ]
>	Oh, J.Y., Rhee, S., Silva, A.J., Lee, Y.S., and Kim, H.K. (2017). Noonan syndrome-associated SHP2 mutation differentially modulates the expression of postsynaptic receptors according to developmental maturation. Neurosci Lett 649, 41-47. [Pubmed ]
>	Kim, D.H., Kang, M., Kim, C.H., Huh, Y.H., Cho, I.H., Ryu, H.H., Chung, K.H., Park, C.S., Rhee, S., Lee, Y.S., et al. (2017). SPIN90 Modulates Long-Term Depression and Behavioral Flexibility in the Hippocampus. Front Mol Neurosci 10, 295. [Pubmed ]
>	Kim, D., You, E., Jeong, J., Ko, P., Kim, J.W., and Rhee, S. (2017). DDR2 controls the epithelial-mesenchymal-transition-related gene expression via c-Myb acetylation upon matrix stiffening. Sci Rep 7, 6847. [Pubmed ]
>	Hwang, K.D., Bak, M.S., Kim, S.J., Rhee, S., and Lee, Y.S. (2017). Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition. Mol Brain 10, 57. [Pubmed ]

>	Ko, P., Kim, D., You, E., Jung, J., Oh, S., Kim, J., Lee, K.H., and Rhee, S. (2016). Extracellular Matrix Rigidity-dependent Sphingosine-1-phosphate Secretion Regulates Metastatic Cancer Cell Invasion and Adhesion. Sci Rep 6, 21564. [Pubmed ]
>	Kim, D., and Rhee, S. (2016). Matrix metalloproteinase2 regulates MDA-MB-231 breast cancer cell invasion induced by active mammalian diaphanous-related formin 1. Mol Med Rep 14, 277-282. [Pubmed ]
>	Kim, D., Jung, J., You, E., Ko, P., Oh, S., and Rhee, S. (2016). mDia1 regulates breast cancer invasion by controlling membrane type 1-matrix metalloproteinase localization. Oncotarget 7, 17829-17843. [Pubmed ]
>	Choi, I.W., Ahn do, W., Choi, J.K., Cha, H.J., Ock, M.S., You, E., Rhee, S., Kim, K.C., Choi, Y.H., and Song, K.S. (2016). Regulation of Airway Inflammation by G-protein Regulatory Motif Peptides of AGS3 protein. Sci Rep 6, 27054. [Pubmed ]
>	Kim, D., Yeom, J.H., Lee, B., Lee, K., Bae, J., and Rhee, S. (2015). Inhibition of discoidin domain receptor 2-mediated lung cancer cells progression by gold nanoparticle-aptamer-assisted delivery of peptides containing transmembrane-juxtamembrane 1/2 domain. Biochem Biophys Res Commun 464, 392-395. [Pubmed ]
>	Kim, D., Kim, S.Y., Mun, S.K., Rhee, S., and Kim, B.J. (2015). Epidermal growth factor improves the migration and contractility of aged fibroblasts cultured on 3D collagen matrices. Int J Mol Med 35, 1017-1025. [Pubmed ]
>	Jang, S.M., Kim, J.W., Kim, C.H., An, J.H., Johnson, A., Song, P.I., Rhee, S., and Choi, K.H. (2015). KAT5-mediated SOX4 acetylation orchestrates chromatin remodeling during myoblast differentiation. Cell Death Dis 6, e1857. [Pubmed ]
>	Kim, K.B., Kim, D.W., Park, J.W., Jeon, Y.J., Kim, D., Rhee, S., Chae, J.I., and Seo, S.B. (2014). Inhibition of Ku70 acetylation by INHAT subunit SET/TAF-Ibeta regulates Ku70-mediated DNA damage response. Cell Mol Life Sci 71, 2731-2745. [Pubmed ]
>	Kim, D., Ko, P., You, E., and Rhee, S. (2014). The intracellular juxtamembrane domain of discoidin domain receptor 2 (DDR2) is essential for receptor activation and DDR2-mediated cancer progression. Int J Cancer 135, 2547-2557. [Pubmed ]
>	Kim, D., You, E., Min, N.Y., Lee, K.H., Kim, H.K., and Rhee, S. (2013). Discoidin domain receptor 2 regulates the adhesion of fibroblasts to 3D collagen matrices. Int J Mol Med 31, 1113-1118. [Pubmed ]
>	Jang, S.M., Kim, J.W., Kim, D., Kim, C.H., An, J.H., Choi, K.H., and Rhee, S. (2013). Sox4-mediated caldesmon expression facilitates differentiation of skeletal myoblasts. J Cell Sci 126, 5178-5188. [Pubmed ]
>	Son, J., Min, N.Y., Choi, J.H., Ko, Y.J., Liang, W., Rhee, S., and Lee, K.H. (2012). Direct evidence of allele-specific binding of CTCF and MeCP2 to Tsix in a HPRT-deficient female F1 hybrid mouse cell line. Cytogenet Genome Res 138, 11-18. [Pubmed ]
>	Min, N.Y., Kim, J.H., Choi, J.H., Liang, W., Ko, Y.J., Rhee, S., Bang, H., Ham, S.W., Park, A.J., and Lee, K.H. (2012). Selective death of cancer cells by preferential induction of reactive oxygen species in response to (-)-epigallocatechin-3-gallate. Biochem Biophys Res Commun 421, 91-97. [Pubmed ]
>	Kim, D., You, E., and Rhee, S. (2012). Dynein regulates cell migration depending on substrate rigidity. Int J Mol Med 29, 440-446. [Pubmed ]
>	Lee, S.J., Yang, S.J., Kim, D.H., Pak, J.H., Lee, K.H., Choi, K.H., Park, D., and Rhee, S. (2011). Interaction of microtubules and actin with the N-terminus of betaPix-b(L) directs cellular pinocytosis. Mol Cell Biochem 351, 207-215. [Pubmed ]

>	Rhee, S., Ho, C.H., and Grinnell, F. (2010). Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis. Exp Cell Res 316, 232-244. [Pubmed ]
>	Jang, S.M., Kim, J.W., Kim, C.H., Kim, D., Rhee, S., and Choi, K.H. (2010). p19(ras) Represses proliferation of non-small cell lung cancer possibly through interaction with Neuron-Specific Enolase (NSE). Cancer Lett 289, 91-98. [Pubmed ]
>	Choi, J.H., Min, N.Y., Park, J., Kim, J.H., Park, S.H., Ko, Y.J., Kang, Y., Moon, Y.J., Rhee, S., Ham, S.W., et al. (2010). TSA-induced DNMT1 down-regulation represses hTERT expression via recruiting CTCF into demethylated core promoter region of hTERT in HCT116. Biochem Biophys Res Commun 391, 449-454. [Pubmed ]
>	Rhee, S. (2009). Fibroblasts in three dimensional matrices: cell migration and matrix remodeling. Exp Mol Med 41, 858-865. [Pubmed ]
>	Jiang, H., Rhee, S., Ho, C.H., and Grinnell, F. (2008). Distinguishing fibroblast promigratory and procontractile growth factor environments in 3-D collagen matrices. FASEB J 22, 2151-2160. [Pubmed ]
>	Rhee, S., and Grinnell, F. (2007). Fibroblast mechanics in 3D collagen matrices. Adv Drug Deliv Rev 59, 1299-1305. [Pubmed ]
>	Rhee, S., Jiang, H., Ho, C.H., and Grinnell, F. (2007). Microtubule function in fibroblast spreading is modulated according to the tension state of cell-matrix interactions. Proc Natl Acad Sci U S A 104, 5425-5430. [Pubmed ]
>	Rhee, S., and Grinnell, F. (2006). P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts. J Cell Biol 172, 423-432. [Pubmed ]
>	Grinnell, F., Rocha, L.B., Iucu, C., Rhee, S., and Jiang, H. (2006). Nested collagen matrices: a new model to study migration of human fibroblast populations in three dimensions. Exp Cell Res 312, 86-94. [Pubmed ]